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为研究妊娠期肝内胆汁淤积症，将妊娠第１５天的清洁级ＳＤ大鼠２０只，随机分成２组，实验组皮下注射１７α乙炔雌二醇（ＥＥ，２．５ｍｇ／ｋｇ·ｄ×５ｄ，溶于丙二醇），对照组注射丙二醇。结果，实验组血清中的丙氨酸转氨酶、天冬氨酸转氨酶和总胆酸较给药前显著升高（Ｐ＜０．０５），胆固醇显著下降（Ｐ＜０．０５），碱性磷酸酶含量无显著改变；肝细胞有空泡变性和坏死，肝内毛细胆管内有胆栓形成。提示ＥＥ可诱发孕鼠肝内胆汁淤积
In order to study intrahepatic cholestasis of pregnancy, 20 clean-grade SD rats on the 15th day of gestation were randomly divided into 2 groups. The experimental group was subcutaneously injected with 17α ethinyl estradiol (EE, 2.5mg / kg · d × 5d , Dissolved in propylene glycol), the control group injected propylene glycol. Results Serum alanine aminotransferase, aspartate aminotransferase and total bile acids were significantly increased (P <0.05), cholesterol was significantly decreased (P <0.05), alkaline phosphatase No significant changes in enzyme content; hepatocytes vacuolar degeneration and necrosis, intrahepatic bile duct gallbladder formation. Tip EE can induce intrahepatic cholestasis in pregnant rats