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目前国内外对顽固性腹水尚无统一诊断标准。顽固性腹水时除有门脉高压和肝功能减退症状外,尚有腹水量多而呈顽固持续的特点。一般认为,凡遇腹水量多而持久,1天应用速尿或安体舒通200mg无利尿作用、尿钠<10mmol/24h、肌酐清除率下降到25～50ml/min(正常80～100ml/min)、最大尿流率2ml/min、24h尿Na/K<0.5(正常>2)、低钠血症或发生肾功能衰竭者,应考虑到顽固性腹水。临床上还常可见到肝硬化长期或大剂量应用利尿剂后对利尿剂产生耐药性,则称为耐药性腹水。对耐药性腹水,如能暂停使用利尿剂、有效控制感
At present, there is no uniform diagnostic criteria for intractable ascites at home and abroad. In addition to intractable ascites, portal hypertension and symptoms of liver dysfunction, there are more than the volume of ascites and persistent characteristics. It is generally believed that any case of ascites volume and lasting, 1 day furosemide or spironolactone 200mg no diuretic effect, urinary sodium <10mmol / 24h, creatinine clearance decreased to 25 ~ 50ml / min (normal 80 ~ 100ml / min ), Maximum flow rate of 2ml / min, 24h urinary Na / K <0.5 (normal> 2), hyponatremia or renal failure, refractory ascites should be considered. Clinically, often can be seen in patients with long-term or high-dose of diuretics after cirrhosis of the diuretic drug resistance, known as drug-resistant ascites. Resistant ascites, if the suspension of diuretics, effective control of flu