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目的 :分析比较尿核基质蛋白 2 2 (NMP2 2 )检测与尿脱落细胞学检查诊断膀胱移行细胞癌的临床价值。方法 :对 12 6例临床怀疑膀胱癌的病人 ,在膀胱镜检查前留取新鲜自排尿 ,分别进行NMP2 2检测和脱落细胞学检查 ,比较 2种方法的敏感性、特异性和阳性预测值。结果 :12 6例中病理证实膀胱移行细胞癌 35例 ,其他疾病 91例。NMP2 2诊断膀胱癌敏感性 82 .9% ,与细胞学 (2 5 .7% )比较 ,差别有极显著性意义 (P <0 .0 1)。即使对浅表性膀胱癌 ,NMP2 2的敏感性也达到 77.8% ,明显优于细胞学的 11.3% (P <0 .0 1)。 2种方法诊断特异性分别为 79.1%和 10 0 .0 %。阳性预测值分别为 6 0 .4 %和 10 0 .0 %。结论 :NMP2 2检测是一种简单、敏感的早期诊断膀胱癌的方法。
Objective: To analyze and compare the clinical value of NMP2 2 detection and urine cytology in the diagnosis of bladder transitional cell carcinoma. Methods: A total of 126 patients with suspected bladder cancer were enrolled in this study. Fresh self-urination was performed before cystoscopy. NMP2 2 and exfoliative cytology were performed respectively. The sensitivity, specificity and positive predictive value of the two methods were compared. Results: Thirty-six bladder transitional cell carcinomas were confirmed in 126 cases and 91 cases of other diseases. The sensitivity of NMP2 2 in diagnosis of bladder cancer was 82.9%, which was significantly different from cytology (25.7%) (P <0.01). Even for superficial bladder cancers, the sensitivity of NMP2 2 to 77.8% was significantly better than that of cytology (P <0.01). The diagnostic specificity of the two methods were 79.1% and 100.0%, respectively. The positive predictive value was 60.4% and 100.0% respectively. Conclusion: NMP2 2 test is a simple and sensitive method for early diagnosis of bladder cancer.