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用传统LBT法和盐析分离皮肤LBT法分别检测SLE106例,BSLE3例,SCLE8例,DLE10例,MCTD15例,PSS11例,DM8例。分离皮肤LBT法阳性率依次为89.6％,1OO％,100％,80％,80％,36％,12.5％;传统LBT法的阳性率依次为50％,100％,75％,80％,33％,18％和0。结果显示分离皮肤LBT法敏感性高于传统LBT法,其中6种疾病的Ig和补体沉积以真皮侧多见,而SCLE患者的Ig和补体在真皮侧与表皮侧的沉积率相等。单独见于表皮侧沉积的只罕见于SLE。Ig和补体以线状沉积比颗粒状多见,而颗粒状沉积者与肾损害关系密切。分离皮肤LBT法方便易行,敏感性高,特异性较强,能更有助于疾病的诊断及鉴别诊断。
Traditional LBT method and salting-out skin LBT method were used to detect SLE106 cases, BSLE3 cases, SCLE8 cases, DLE10 cases, MCTD15 cases, PSS11 cases and DM8 cases respectively. The positive rate of LBT was 89.6%, 100%, 100%, 80%, 80%, 36% and 12.5% respectively. The positive rates of LBT were 50%, 100%, 75%, 80%, 33 %, 18% and 0. The results showed that the skin LBT method was more sensitive than the traditional LBT method. Ig and complement deposition were more common in the dermis than in the six diseases, while the deposition rates of Ig and complement on the dermis and epidermis were the same in SCLE patients. Only found in the epidermis side of the deposition is rare in SLE. Ig and complement to linear deposition more common than granular, and granular deposits of kidney damage are closely related. LBT skin separation method is easy and convenient, high sensitivity, strong specificity, can be more helpful in the diagnosis and differential diagnosis of the disease.