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本文旨在确定反复性败血症时肺循环与体循环反应的关系。作者采用12头45～60 kg成年绵羊,均制备成慢性肺淋巴痿。每日2次经静脉给予大肠杆菌内毒素(1μg/kg),共5天,继续观察3天。初3次给予内毒素后肺反应特征为严重的肺动脉高压、缺氧,肺淋巴流量增加2～3倍,肺淋巴和血浆TXB_2及6-酮-pGF 1α水平从200 pg/ml左右增高至2000 pg/ml以上。体循环对起初数次注射内毒素的反应是周围血管阻力升高、心指数降低、氧耗量暂时升高20％。继续给予内毒素后,肺反应显著减弱。肺动脉压、肺淋巴流量和动脉氧张力仅中度改变。TXB_2增高不到800 pg/ml。6-酮-PGF1α无改变。但此时高动力状态呈进行性发展,特点是心指
This article aims to determine the relationship between pulmonary circulation and systemic circulation during recurrent septicemia. The authors used 12 45 ~ 60 kg adult sheep, were prepared for chronic lung lymph syndrome. Esophageal endotoxin (1 μg / kg) was intravenously administered twice daily for 5 days and observation was continued for 3 days. Pulmonary responses to the first 3 doses of endotoxin were characterized by severe pulmonary hypertension with an increase in hypoxia, an increase in lung lymphatic flow by 2 to 3 times, an increase in pulmonary and plasma TXB2 and 6-keto-pGF1alpha from 200 pg / ml to about 2000 pg / ml or more. The systemic circulation of the first few injections of endotoxin response is increased peripheral vascular resistance, cardiac index decreased, the temporary increase in oxygen consumption by 20%. After continuing to endotoxin, lung response was significantly reduced. Pulmonary arterial pressure, pulmonary lymphatic flow, and arterial oxygen tension were moderately altered. TXB_2 increased by less than 800 pg / ml. 6-keto-PGF1α was unchanged. But at this time high dynamic state was progressive development, characterized by the heart