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目的探讨阿托伐他汀对自发性高血压大鼠(SHR)动脉血压和血管内皮功能的影响。方法选用8周龄SHR12只,随机分为阿托伐他汀治疗组(ATV组,n=6)、蒸馏水组(DW组,n=6),另选6只WKY大鼠作为正常对照。ATV组大鼠给以阿托伐他汀50mg/(kg·d)加适量蒸馏水灌胃。DW组和WKY组每天同时用等量蒸馏水灌胃。观察给药前后大鼠尾动脉血压的变化,测定大鼠血清总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)浓度,观察血浆内皮素1(ET-1)水平、主动脉组织一氧化氮合酶(NOS)活性的变化特点。结果ATV组大鼠动脉血压显著低于DW组(P＜0．01)；与DW组和WKY组比较,ATV组血清TC、TG和HDL-C浓度显著降低(P＜0．01,P＜0．05)；DW组血清ET-1水平显著高于WKY组(P＜0．05),主动脉组织NOS活性显著低于WKY组(P＜0．05),经ATV治疗后血清ET-1水平明显降低(P＜0．05),而主动脉组织NOS活性显著增高(P＜0．01)。结论长期应用阿托伐他汀可以显著降低动脉血压。阿托伐他汀通过改善血管内皮功能延缓高血压的病理过程。
Objective To investigate the effects of atorvastatin on arterial blood pressure and endothelial function in spontaneously hypertensive rats (SHR). Methods SHR 12 rats of 8 weeks old were randomly divided into atorvastatin treatment group (ATV group, n = 6), distilled water group (n = 6) and another 6 WKY rats as normal control. ATV rats were given atorvastatin 50mg / (kg · d) plus appropriate amount of distilled water gavage. DW group and WKY group with the same amount of distilled water daily gavage. The changes of rat tail artery blood pressure before and after administration were observed. The concentrations of total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) ) Levels, aorta tissue nitric oxide synthase (NOS) activity changes. Results The blood pressure of ATV group was significantly lower than that of DW group (P <0.01). Compared with DW group and WKY group, the concentrations of TC, TG and HDL-C in ATV group were significantly decreased (P <0.01, P < 0.05). The serum level of ET-1 in DW group was significantly higher than that in WKY group (P <0.05), NOS activity in aortic tissue was significantly lower than that of WKY group (P <0.05) 1 level was significantly lower (P <0.05), while the aortic NOS activity was significantly increased (P <0.01). Conclusion Long-term use of atorvastatin can significantly reduce arterial blood pressure. Atorvastatin slows the pathological process of hypertension by improving endothelial function.