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目的观察白及苦参汤保留灌肠联合柳氮磺胺吡啶治疗溃疡性结肠炎的临床疗效。方法将58例溃疡性结肠炎患者随机分为联合治疗组和对照组,联合治疗组予白及苦参汤保留灌肠并同时口服柳氮磺胺吡啶,对照组仅给予柳氮磺胺吡啶口服治疗。观察和比较两组临床治疗效果及不良反应。结果联合治疗组总有效率为86.7%,对照组为67.9%,两组比较差异有统计学意义(P<0.05)。两组患者治疗过程中未见明显不良反应。结论白及苦参汤保留灌肠联合柳氮磺胺吡啶治疗溃疡性结肠炎安全有效,值得临床推广应用。
Objective To observe the curative effect of reserpine and kushen decoction combined enema with sulfasalazine in the treatment of ulcerative colitis. Methods Fifty-eight patients with ulcerative colitis were randomly divided into combined treatment group and control group. The combined treatment group was treated with Baikishen and Kushen Decoction and orally with sulfasalazine. The control group was given sulfasalazine only orally. The clinical effects and adverse reactions in both groups were observed and compared. Results The total effective rate was 86.7% in the combined treatment group and 67.9% in the control group, with significant difference between the two groups (P <0.05). Two groups of patients with no significant adverse reactions during treatment. Conclusion White and Kushen Decoction retention enema combined with sulfasalazine for the treatment of ulcerative colitis safe and effective, worthy of clinical application.