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自从1983年Warren和Marshell在人胃内发现一种产尿素的螺旋形微生物—幽门螺旋杆菌(Helicobater polic,HP)以来,HP与胃炎和消化性溃疡的发病成为消化内科的研究热点。现已证明,HP是胃炎及胃溃疡的发病重要因素之一。其假说主要有二个:①胃泌素相关假说;②漏屋假说。近年来Talley等人首先提出HP与胃腺癌的发病有关。日本学者Hirai M、MatsukuraN、和美国学者Vollwers等,在HP致癌机理中作了进一步研究。本文就HP致癌机理研究中的新观点和新证据作如下综术。 1 胃癌患者血清和空泡毒素具有较高亲和力
Since Warren and Marshell discovered a urea-producing helicobacter strain Helicobacter pylori (HP) in the human stomach in 1983, the incidence of HP and gastritis and peptic ulcer has become a research hot spot in the department of gastroenterology. It has been proved that HP is one of the important factors in the pathogenesis of gastritis and gastric ulcer. There are two main hypotheses: 1 gastrin-related hypothesis; 2 leakage house hypothesis. In recent years Talley et al. first proposed that HP is associated with the onset of gastric adenocarcinoma. Japanese scholars Hirai M, Matsukura N, and American scholar Vollwers, etc., made further studies in the mechanism of HP carcinogenesis. In this paper, the following new perspectives and new evidence in the research on the mechanism of HP carcinogenesis are summarized as follows. 1 Gastric cancer patients have high affinity with vacuolar toxin and serum