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近来,经蝶骨垂体手术治疗肢端肥大症已引起较多的关注,因其有可能去除生长激素(GH)过度分泌而保留正常垂体功能。作者报告应用经蝶骨选择性垂体腺瘤摘除术治疗11例活动性肢端肥大症的经验。11例(男8,女3例)患者,年龄29～69(平均50)岁,均有典型肢端肥大症的临床表现,其中10例头颅 X 线片或蝶鞍 X 线断层照片示垂体肿瘤之异常征象,1例 X 线表现正常。术前平均空腹 GH 浓度为23ng/ml(14～39ng/ml),葡萄糖抑制后最低 GH浓度平均值为15ng/ml(8.6～29ng/ml),1例未测葡萄糖抑制后最低 GH 浓度。本文尚测定20(女8,男12)名健康志愿者空腹和葡萄糖抑制后 GH 浓度。
Recently, transaposal pituitary surgery for acromegaly has attracted more attention as it is possible to remove the excessive secretion of growth hormone (GH) while retaining normal pituitary function. The authors report the application of transsphenoidal pituitary adenoma excision in the treatment of 11 cases of active acromegaly experience. Eleven patients (8 males and 3 females), aged from 29 to 69 (mean age 50 years), had typical acromegaly clinical manifestations. Among them, 10 cases of skull X-ray or sella radiograph showed pituitary tumors The abnormal signs, 1 case of X-ray showed normal. The average fasting preoperative GH concentration was 23 ng / ml (14-39 ng / ml), the mean minimum GH concentration after glucose suppression was 15 ng / ml (8.6-29 ng / ml), and the lowest GH concentration after glucose inhibition was not measured. This article still measured 20 (female 8, male 12) healthy volunteers fasting and glucose suppression after GH concentration.