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目的研究分析新生儿呼吸窘迫综合征应用盐酸氨溴索治疗的临床疗效。方法 80例新生儿呼吸窘迫综合征患儿,随机分为对照组及观察组,每组40例。对照组患儿进行常规对症治疗,观察组患儿在常规对症治疗的基础上给予盐酸氨溴索治疗。比较两组患儿治疗前后的[动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)、氧合指数(PaO_2/FiO_2)]指标水平及患儿的氧疗时间、住院时间、并发症发生情况。结果治疗前,两组患儿的PaO_2、PaCO_2、PaO_2/FiO_2比较,差异均无统计学意义(P>0.05);治疗后,两组患儿的PaO_2较治疗前升高,PaCO_2、PaO_2/FiO_2较治疗前下降,且观察组改善程度优于对照组,差异均具有统计学意义(P<0.05)。观察组患儿的氧疗时间(62±16)h、住院时间(13.7±6.5)d、并发症发生率(2.5%)均优于对照组[(93±19)h、(19.3±7.9)d、17.5%],差异均具有统计学意义(P<0.05)。结论盐酸氨溴索用于治疗新生儿呼吸窘迫综合征具有较好的临床效果,不但可以改善患儿的血气分析指标,还可缩短患儿的氧疗时间和住院时间,降低不良反应发生率,值得在临床中广泛推广。
Objective To study the clinical efficacy of ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome. Methods Eighty neonates with respiratory distress syndrome were randomly divided into control group and observation group, 40 cases in each group. The control group of children with conventional symptomatic treatment, observation group of children given routine ambroxol treatment based on ambroxol hydrochloride. The levels of PaO_2, PaCO_2 and PaO_2 / FiO_2 before and after treatment were compared between the two groups in terms of oxygen therapy time, hospitalization time, and complications Occurrence of disease. Results Before treatment, PaO_2, PaCO_2 and PaO_2 / FiO_2 in both groups had no significant difference (P> 0.05). After treatment, the PaO_2 in both groups were higher than those before treatment, PaCO_2, PaO_2 / FiO_2 Compared with before treatment decreased, and the observation group improved better than the control group, the differences were statistically significant (P <0.05). Oxygen therapy time (62 ± 16) h, hospital stay (13.7 ± 6.5) days and complication rate (2.5%) in observation group were better than those in control group [(93 ± 19) h, (19.3 ± 7.9) d, 17.5%], the differences were statistically significant (P <0.05). Conclusion Ambroxol Hydrochloride for the treatment of neonatal respiratory distress syndrome has a good clinical effect, not only can improve children’s blood gas analysis indicators, but also shorten the oxygen treatment time and hospital stay, reduce the incidence of adverse reactions, Worth widely in clinical promotion.