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目的:观察宫颈癌组织中miR-186与EGFR表达的关系及对宫颈癌细胞增殖、侵袭及凋亡的影响.方法:收集我院2020年6月～2020年12月宫颈癌组织标本36份,采用PCR检测miR-186与EGFR m RN A表达,比较不同FIGO分期、不同病理类型、分化程度及是否伴淋巴结转移宫颈癌组织miR-186与EGFR m RN A表达水平,采用Spearman相关分析FIGO分期、肿瘤分化、淋巴结转移与miR-186、EGFR m RN A的相关性.结果:miR-186表达:FIGO分期Ⅱ期低于Ⅰ期,低分化“,”Objective: To observe the relationship between miR-186 and EGFR expression in cervical cancer and its influence on proliferation, invasion and apoptosis of cervical cancer cells. Methods: Thirty-six cervical cancer specimens were collected from January 2020 to December 2020 in our hospital, and the expressions of miR-186 and EGFR m RN A were detected by PCR. The expressions of miR-186 and EGFR m RN A in cervical cancer tissues with different FIGO stages, different pathological types, different degrees of differentiation and lymph node metastasis were compared. Spearman correlation was used to analyze FIGO stages, tumor differentiation, lymph node metastasis and miR-186 and EGFR M Rna. Results: miR-186 expression: FIGO stage ⅱ was lower than stage ⅰ, and low differentiation was lower than high differentiation; Lymph node metastasis is higher than lymph node metastasis. The difference was statistically significant (P ＜ 0.05). EGFR m RN A expression: FIGO stage ⅱ was higher than stage ⅰ; Low differentiation is higher than high differentiation. Lymph node metastasis is lower than lymph node metastasis. The difference was statistically significant (P ＜ 0.05). The expression levels of miR-186 and EGFR m RN A in squamous cell carcinoma and adenocarcinoma were not significantly different (p ＞ 0.05). The FIGO stage was negatively correlated with miR-186 and positively correlated with EGFR m RN A (r=-0.582, 0.429, P=0.010, 0.023). Tumor differentiation was negatively correlated with miR-186 and positively correlated with EGFR m RN A (r=-0.602, 0.473,P=0.007, 0.017). Lymph node metastasis was negatively correlated with miR-186 and positively correlated with EGFR m RN A (r=-0.529, -0.376, P=0.013, 0.028). Conclusion: The proliferation, invasion and apoptosis of cervical cancer cells are related to the expression of miR-186- and EG FR, suggesting that miR-186 may inhibit the proliferation, invasion and apoptosis of cancer cells by inhibiting EGFR expression.