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在多种类型细胞中含有一类多肽分子,它们具有刺激细胞生长和维持细胞活力的功能,称为多肽生长因子(PGF)。在过去几年中这个领域的主要成就有下列三个方面,一,进行了许多PGF的分离和纯化及其鉴定,证明了它们确是存在的,二、阐明了一部分PGF的结构,并比较了不同PGF部分结构的相似性,三、发现了一些PGF的受体,受体的交叉反应,并阐明了受体的结构和功能。此外,除了刺激细胞生长之外,还发现每种PGF各有其独特的生物学效应。然而从近来PGF研究的发展看,一般认为这类多肽已成生物发育的重要因素。
In many types of cells contains a class of peptide molecules, they have to stimulate cell growth and maintain cell viability function, known as polypeptide growth factor (PGF). The main achievements in this field in the past few years are as follows: First, many PGFs have been isolated and purified and their identification proved that they exist. Second, the structure of a part of PGF was clarified and compared Different parts of the PGF structure similarities, three, found some PGF receptor, receptor cross-reactivity, and elucidate the structure and function of the receptor. In addition, in addition to stimulating cell growth, each PGF has been found to have its own unique biological effect. However, from the recent development of PGF research, it is generally considered that such polypeptides have become an important factor in biological development.