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目的探讨联合应用口服美沙拉嗪联合灌肠方式对溃疡性结肠炎进行治疗的临床效果。方法选择2011年12月—2014年12月期间本院收治的76例溃疡性结肠炎患者为研究对象,随机平分为对照组、观察组各38例。对照组给予口服美沙拉嗪缓释颗粒进行治疗,3次/d,1.0 g/次。观察组在对照组的治疗基础上加用美沙拉嗪灌肠剂保留灌肠,1次/晚,每次4 g/100 ml。连续治疗1个疗程,对2组患者的治疗效果进行对比分析。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组、对照组的治疗总有效率分别为94.74%、84.21%,观察组显著高于对照组,对比差异有统计学意义(P<0.05)。治疗后,观察组患者的CRP为(2.21±1.62)mg/L,Fid为(2.56±0.35)g/L,MPV为(10.87±0.68)fl。对照组患者的CRP为(5.62±2.61)mg/L,Fid为(2.89±0.62)g/L,MPV为(10.11±1.03)fl,对比差异均有统计学意义(均P<0.05)。观察组的不良反应发生率为5.26%,显著低于对照组的26.32%,对比差异有统计学意义(P<0.05)。结论应用美沙拉嗪口服联合灌肠的方式对溃疡性结肠炎进行治疗可取得更为理想的治疗效果,且安全性更高。
Objective To investigate the clinical effect of combined oral mesalazine and enema on ulcerative colitis. Methods A total of 76 patients with ulcerative colitis admitted to our hospital from December 2011 to December 2014 were randomly divided into control group (n = 38) and observation group (n = 38). Control group was given oral mesalazine sustained-release particles for treatment, 3 times / d, 1.0 g / time. Observation group in the control group based on the treatment with mesalamine enema retention enema, 1 / night, each 4 g / 100 ml. Continuous treatment of a course of treatment, the two groups of patients treated for comparative analysis. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rates of the observation group and the control group were 94.74% and 84.21% respectively. The observation group was significantly higher than that of the control group (P <0.05). After treatment, the CRP in the observation group was (2.21 ± 1.62) mg / L, the Fid was (2.56 ± 0.35) g / L and the MPV was (10.87 ± 0.68) fl. The CRP in the control group was (5.62 ± 2.61) mg / L, the Fid was (2.89 ± 0.62) g / L and the MPV was (10.11 ± 1.03) fl respectively. The difference was statistically significant (all P <0.05). The incidence of adverse reactions in the observation group was 5.26%, which was significantly lower than that in the control group (26.32%), the difference was statistically significant (P <0.05). Conclusion The application of mesalazine combined with oral enema on the treatment of ulcerative colitis can be obtained more satisfactory treatment, and more secure.