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（２Ｒ，３Ｓ）Ｎ苯甲酰基３苯基异丝氨酸，是抗癌新药紫杉醇的侧链。利用苯甲醛和氯乙酸乙酯为原料，在甲醇钠作用下，０℃经Ｄａｒｚｅｎ反应２４ｈ，蒸去甲醇，乙醚萃取，减压蒸馏得到反式３苯基缩水甘油酸乙酯（４），４的甲醇溶液与ＮＨ３在１００℃中压下氨解，在Ｖ（ＣＨ２Ｃｌ２）／Ｖ（ＣＨ３ＯＨ）＝１∶１溶剂中结晶得赤式３苯基异丝氨酰胺（５），５在１００℃用Ｂａ（ＯＨ）２水解８ｈ，得到赤式３苯基异丝氨酸（６），６与苯甲酰氯于０℃下在ｗ（ＮａＨＣＯ３）＝１０％的溶液中发生酰化反应，Ｖ（ＴＨＦ）／Ｖ（ＣＨ２Ｃｌ２）＝４∶１溶剂萃取，粗产物在Ｖ（石油醚）／Ｖ（丙酮）＝４０∶１溶剂中结晶，得到赤式Ｎ苯甲酰基３苯基异丝氨酸，四步反应总产率为２８．４％。用ＩＲ、１ＨＮＭＲ、元素分析验证了化合物的结构。
(2R, 3S) N benzoyl 3 phenyl isoserine, is a side chain of anticancer drug paclitaxel. Using benzaldehyde and ethyl chloroacetate as raw materials, under the action of sodium methoxide, Darzen reaction is carried out at 0 DEG C for 24 hours, the methanol is distilled off and the ether is extracted and distilled under reduced pressure to obtain trans-3-phenylglycidyl ethyl ester (4) , 4 methanol solution and NH3 at 100 ° C under pressure ammonia solution, in the V (CH2Cl2) / V (CH3OH) = 1: 1 solvent crystallization was erythro 3 phenylisoserine amide (5), 5 Hydrolysis of Ba (OH) 2 at 100 ℃ for 8h gave erythro-3-phenylisoserine (6). 6 Acylation reaction between benzoyl chloride and benzoyl chloride at 0 ℃ in w (NaHCO3) = 10% , V (THF) / V (CH2Cl2) = 4: 1, the crude product was crystallized from V (petroleum ether) / V (acetone) = 40: 1 solvent to obtain erythro Nbenzoyl 3 Phenylisoserine, the overall yield of the four-step reaction was 28.4%. The structure of the compound was confirmed by IR, 1HNMR, elemental analysis.