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目的:分析疫苗在冷链运输各个环节的效价变化,评价广东省冷链系统运转状况。方法:采用线性监测与定点监测结合,连续抽检麻疹减毒活疫苗(MV),依照卫生部规程,采用微量细胞培养法,测定疫苗的效价。结果:共抽检MV204批次,合格率99.5%,平均病毒滴度为4.15log CCID50/ml,省、市、县三级抽样结果差异没有显著性,不同年份疫苗检验结果有差异。结论:广东省冷链系统运转情况良好,疫苗效价在运输过程中没有降低。
OBJECTIVE: To analyze the change of potency of vaccines in various links of cold chain transportation and evaluate the operation status of cold chain in Guangdong Province. Methods: The live attenuated measles vaccine (MV) was continuously detected by the combination of linear monitoring and site-directed monitoring. The titer of the vaccine was determined by the method of ministerial culture in accordance with the regulations of the Ministry of Health. Results: A total of 20 batches of MV204 were selected with a pass rate of 99.5% and an average virus titer of 4.15 log CCID50 / ml. There was no significant difference in sampling results between provinces, cities and counties, and there were differences in vaccine test results in different years. Conclusion: The cold chain system in Guangdong operated in good condition and the vaccine potency did not decrease during transport.