论文部分内容阅读
目的:探讨P53和P21ras基因在正常子宫内膜、子宫内膜非典型增生和子宫内膜癌中表达情况,及其表达在病理诊断中的意义。方法:应用免疫组织化学方法检测15例正常子宫内膜、12例子宫内膜非典型增生和35例子宫内膜癌中P53和P21ras的表达情况。结果:15例正常子宫内膜中P53和P21ras基因表达阴性;12例子宫内膜非典型增生中2例P53阳性(16.6%)、1例P21ras阳性(8.3%);在子宫内膜癌中P53阳性20例(57.1%)、17例P21ras阳性(48.0%)。结论:P53和P21ras基因在子宫内膜增生性疾病中均有表达,在子宫内膜癌中高表达(,P<0.05),对子宫内膜癌的病理诊断提供有力依据。
Objective: To investigate the expression of P53 and P21ras gene in normal endometrium, endometrial dysplasia and endometrial carcinoma and its significance in pathological diagnosis. Methods: Immunohistochemistry was used to detect the expression of P53 and P21ras in 15 cases of normal endometrium, 12 cases of endometrial dysplasia and 35 cases of endometrial carcinoma. Results: The expression of P53 and P21ras was negative in 15 cases of normal endometrium. Among the 12 cases of endometrial atypical hyperplasia, 2 cases were P53 positive (16.6%) and 1 case P21ras positive (8.3%). In endometrial carcinoma, P53 Positive in 20 cases (57.1%), 17 cases of P21ras positive (48.0%). Conclusion: The expression of P53 and P21ras genes in endometrial hyperplasia is highly expressed in endometrial carcinoma (P <0.05), which provides a strong evidence for the pathological diagnosis of endometrial carcinoma.