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[目的]观察三桑肾气汤联合西药治疗肾气虚型慢性阻塞性肺疾病疗效。[方法]使用随机平行对照方法,将140例住院及门诊患者按抛硬币法简单随机分为两组。对照组70例Ⅰ级:沙丁胺醇,咳嗽、咳痰或呼吸困难不能自抑时喷1次,仍不缓解加喷1次,<8次/d;II级、III级、IV级:沙丁胺醇,咳嗽、咳痰或呼吸困难不能自抑时喷1次,仍不缓解加喷1次,<8次/d;沙美特罗替卡松,1喷/次,2次/d。氧疗,2L/min,16h/d。治疗组70例三桑肾气汤(桑椹~(川、晒干)、桑寄生~(粤、晒干)、桑白皮~(蜜炙)、补骨脂~(豫、盐炙)、杜仲~(川、盐炙)各9g,女贞子~(川、酒炙)、黄精~(冀、酒炙)各12g;肺气虚加黄芪~(内蒙古、蜜炙)12g,白术~浙、防风~(冀、晒)干各9g;脾气虚加党参~(川、晒干)、茯苓~云各12g,甘草~(内蒙古、蜜炙)6g,陈皮~(粤、晒干)、半夏~(川、姜炙)、白术~(麸炒)各9g;肝气郁滞加柴胡~(冀、醋炙)、前胡~(浙、蜜炙)、赤芍~(川、晒干)、白芍~(浙、酒炒)各9g,青皮~(粤、醋炙)、陈皮~(粤、晒干)各6g),1剂/d,水煎300m L,早晚口服,150m L/次;西药治疗同对照组。连续治疗90d为1疗程。观测临床症状、6分钟步行距离、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效26例,有效33例,无效11例,总有效率84.29%。对照组显效8例,有效40例,无效22例,总有效率68.57%。治疗组疗效优于对照组(P<0.05)。治疗组6分钟步行距离有改善(P<0.05),对照组无改善(P>0.05),治疗组优于对照组(P<0.05)。[结论]三桑肾气汤联合西药治疗肾气虚型慢性阻塞性肺疾病疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of “San Sang Shen Qi Decoction” combined with western medicine on chronic obstructive pulmonary disease of kidney-qi deficiency type. [Methods] Using randomized parallel control method, 140 inpatients and outpatients were randomly divided into two groups according to the coin tossing method. Control group of 70 patients with grade Ⅰ: salbutamol, cough, sputum or dyspnea can not be suppressed when the spray 1, still not relieve plus spray 1, <8 times / d; II, III, IV: salbutamol, cough , Sputum or dyspnea can not be suppressed when the spray 1, still do not ease plus spray 1, <8 times / d; salmeterramorph, 1 spray / time, 2 times / d. Oxygen therapy, 2L / min, 16h / d. The treatment group, 70 cases of three Sang Shenqi Decoction (mulberry ~ (Sichuan, dried), parasitic ~ (Guangdong, dried), Morus alba (honey Sunburn), psoralen ~ 12g, Astragalus ~ (Inner Mongolia, Honey Sunburn) 12g, Atractylodes ~ Zhejiang, windproof ~ (Sichuan, salt Sunburn) of the 9g, Ligustrum lucidum ~ (Ji, sun) dry the 9g; spleen qi plus Codonopsis ~ (Sichuan, dried), Poria ~ 12g of cloud, licorice ~ (Inner Mongolia, honey Sunburn) 6g, dried tangerine peel ~ (Sichuan, ginger Sunburn), Atractylodes ~ (bran fried) each 9g; liver qi stagnation plus Bupleurum ~ (Hebei, vinegar Sunburn) White peony root (Zhejiang, wine fried) each 9g, Qingpi ~ (Guangdong, vinegar Sunburn), dried tangerine peel ~ (Guangdong, dried) each 6g), 1 / d, decoction 300m L, morning and evening oral, 150m L / Western medicine treatment with the control group. Continuous treatment of 90d for a course of treatment. Observed clinical symptoms, 6 minutes walking distance, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group was effective in 26 cases, effective in 33 cases, ineffective in 11 cases, the total effective rate was 84.29%. The control group was effective in 8 cases, effective in 40 cases, ineffective in 22 cases, the total effective rate was 68.57%. The treatment group was better than the control group (P <0.05). The treatment group had a 6-minute walking distance improvement (P <0.05), no improvement in the control group (P> 0.05), and the treatment group was superior to the control group (P <0.05). [Conclusion] Sanshen Shenqi Decoction combined with western medicine has satisfactory curative effect on chronic obstructive pulmonary disease of kidney-qi deficiency without serious adverse reactions and is worth popularizing.