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不同程度的营养不良常伴发于各类压疮、糖尿病足等慢性创面患者，有效的营养支持是处置慢性创面的基础。锌是人体必需营养物质，具有广泛的生理作用。大量的临床实践发现，改善全身或创面局部锌营养状态可促进不同类型的创面修复，其机制至少包括：改善食欲和加强营养物质吸收、拮抗创面过氧化损伤、抑制修复细胞凋亡、激活相关生长因子表达及信号通路等。“,”Different degrees of malnutrition are often associated with the patients with various chronic wounds such as pressure ulcer and diabetic foot.Effective nutritional support is the basis for the treatments of chronic wounds.Zinc is one of the essential trace elements with extensive physiological functions .It has been proved by a lot of clinical practices that improvement of overall zinc nutrition status or wound surface could pro-mote wounds healing.The mechanisms include at least the following:enhancing appetite,alleviating oxidative impairments,inhabiting apoptosis,and activating expression of related growth factors and signaling pathway.