CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtu

• 作 者: Danmin Ou Lin Chen Jiang He Zh
• 机 构: DepartmentofOncology,internationalCooperationBaseofCancerPrecisionTherapy,KeyLaboratoryofMolecularRa
• 出 处: 癌症生物学与医学:英文版
• 发表日期: 2020年2期
• 关键词: Wnt/β-catenin signaling CDK11 ENDOSOME MICROTUBULE SIRT2
• 基金项目: grants from the National Natural Science Foundation of China(Grant No.81530084,81874200,and 81572750),the Hunan Science and Technology Department(Grant No.2018RS3028),Central South University(Grant No

Objectives:Improper activation of Wnt/β-catenin signaling has been implicated in human diseases.Beyond the well-studied glycogen synthase kinase 3p(GSK3p)and casein kinase 1(CK1),other kinases affecting Wnt/β-catenin signaling remain to be defined.Methods