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药品中硫酸盐的限度试验,中国药典中规定有两种方法:第一法以 N/10硫酸作比较,第二法以硫酸钾作比较。但药典在操作条件上的规定不具体,因此做出的混浊度,结果往往相差很大。如果标准品的混浊度相差大,就无法作为标准来测定药品中硫酸盐的限度。为此,以中国药典的两种方法为基础,做了一系列的比较,初步结果如下。一理论部份硫酸根的检查原理是用加稀的氯化钡水溶液与SO_4~-生成硫酸钡微细混浊的方法来比较混浊度。Ba~(++)+SO_4~(?)→BaSO_4↓硫酸钡在水中、酸、硷中溶解度均极小,故以它为标准是很恰当的.为了避免检品中所存在的杂质与 Ba~(++)生成沉淀干扰检查,故要求在溶液中加稀盐酸,使它们在酸中溶
Drug sulfate limit test, the Chinese Pharmacopoeia there are two ways: the first method to compare N / 10 sulfuric acid, the second method to compare potassium sulfate. However, pharmacopoeia in the operating conditions of the specific, so to make the turbidity, the results are often very different. If the standard turbidity difference between the large, it can not be used as a standard to determine the limits of sulfate drugs. To this end, based on the two methods of Chinese Pharmacopoeia, a series of comparisons are made. The preliminary results are as follows. A theoretical part of the sulfate test principle is to use dilute barium chloride aqueous solution and SO_4 ~ - generated fine haze barium sulfate method to compare turbidity. Ba ~ (++) + SO_4 ~ (?) → BaSO_4 ↓ barium sulfate solubility in water, acid, alkaline are very small, so it is very appropriate to it as standard.In order to avoid the presence of impurities and seizure of Ba ~ (++) generate precipitation interference check, it is required in the solution plus dilute hydrochloric acid, so that they are dissolved in acid