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目的 奥美拉唑具有强大的抑制胃酸分泌的作用 ,常用剂量为 2 0mg。因此 ,探讨小剂量奥美拉唑镁肠溶片 (洛赛克MUPS ,1 0mg)对健康成人 2 4h胃内 pH变化的影响。 方法 利用Digitrap perMKⅢ动态 pH监测仪观察 1 2例健康志愿者 2 4h胃内pH变化节律 ,次日晨 8时口服奥美拉唑镁肠溶片 1 0mg ,并复查 2 4h胃内 pH。经过 1周清洗期后 ,其中 1 1例受试者再予以奥美拉唑镁肠溶片 1 0mg ,每日 1次 ,连续 6d ,并于第 6天复查 2 4h胃内pH。 结果 奥美拉唑镁肠溶片 1 0mg顿服后 ,2 4h胃内 pH中位值由 1 .0 0升高至 1 .2 0 ,2 4h胃内平均pH值、pH >3总时间百分比、pH >4总时间百分比及pH >5总时间百分比分别由 1 .56± 0 .34 ,(1 8.44± 7.55) % ,(1 2 .0 5± 6 .1 0 ) % ,(6 .89± 4 .40 ) %升高至 2 .1 8± 0 .65(P <0 .0 1 ) ,(34 .40± 1 2 .73) % (P <0 .0 1 ) ,(2 3 .58± 1 0 .59) % (P <0 .0 1 )及 (1 3 .58± 8.36) % (P <0 .0 5)。奥美拉唑镁肠溶片 1 0mg ,每日 1次 ,连续 6d后 ,2 4h胃内 pH中位值升高至 3 .2 0 ,2 4h胃内平均 pH值、pH >3总时间百分比、pH >4总时间百分比及 pH >5总时间百分比分别升高至 4 .30± 1 .61 ,(59.2 1± 2 1 .37) % ,(48.1 3± 2 3 .2 4 ) %及 (36 .85± 2 2 .62 ) % ,均显?
Purpose Omeprazole has a strong inhibitory effect on gastric acid secretion, commonly used dose of 20mg. Therefore, to investigate the effects of low-dose omeprazole magnesium enteric-coated tablets (Losec MUPS, 10 mg) on changes of intragastric pH in healthy adults for 24 h. Methods Digitrap perMKⅢ dynamic pH monitor was used to observe the changes of intragastric pH in 24 healthy volunteers at 12 hours. Omeprazole magnesium enteric-coated tablets (10 mg) were orally administered at 8:00 am the next morning, and the intragastric pH was reviewed. After 1-week washout period, 11 of the subjects were given 10 mg omeprazole magnesium enteric-coated tablets once daily for 6 days, and the intragastric pH was reviewed on the 6th day. Results omeprazole magnesium enteric-coated tablets 10mg Day service, 24 hours gastric median pH increased from 1. 0 to 1.20, 24 hours gastric average pH value, pH> 3 total time percentage , PH> 4 total time percentage and pH> 5 total time percentage increased from 1.56 ± 0.34, (1 8.44 ± 7.55)%, (12.0 ± 6.01)%, (6.89 ± 4.40)% to 2.18 ± 0.65 (P <0. 01), (34 .40 ± 122.73)% (P <0. 58 ± 1 0 .59)% (P <0.01) and (1 .58 ± 8.36)% (P <0. 05). Omeprazole magnesium enteric-coated tablets 10mg once daily for 6d after 24h gastric median pH value increased to 3.20, 24h gastric average pH value, pH> 3 total time percentage , PH> 4 total time percentage and pH> 5 total time percentage increased to 4.30 ± 1.61, (59.2 1 ± 21.37)%, (48.1 3 ± 23.24)% and ( 36 .85 ± 2 2 .62)%, all significant?