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目的分析玫瑰解郁方联合生物反馈治疗维持性血液透析(MHD)患者抑郁症临床疗效。方法将56例MHD合并抑郁抑郁症患者按随机法分为对照组和观察组,每组28例。对照组患者给予盐酸帕罗西汀片治疗,观察组患者给予玫瑰解郁方联合生物反馈治疗。分别于治疗前后采用汉密尔顿抑郁量表(HAMD)及汉密尔顿焦虑量表(HAMA)评价患者抑郁、焦虑情绪;于治疗2周后、治疗4周后采用不良反应量表(TESS)评价患者用药后不良反应情况;并比较两组临床疗效。结果观察组总有效率为92.86%明显大于对照组的71.43%,差异有统计学意义(P<0.05)。治疗后,两组患者HAMD、HAMA评分较治疗前均明显降低,且观察组较对照组HAMD、HAMA评分降低更显著,差异有统计学意义(P<0.05);用药4周后,观察组较对照组TESS评分明显降低,差异有统计学意义(P<0.05)。结论玫瑰解郁方联合生物反馈治疗维持性血液透析患者抑郁症可明显改善MHD抑郁患者抑郁情绪,提高临床疗效,且副作用较小,可在临床推广。
Objective To analyze the clinical efficacy of Rose Jieyu Decoction combined with biofeedback in the treatment of depression in maintenance hemodialysis (MHD) patients. Methods 56 MHD patients with depression and depression were randomly divided into control group and observation group, 28 cases in each group. Patients in the control group were treated with paroxetine hydrochloride tablets, and patients in the observation group were treated with Rose Jieyu Decoction combined with biofeedback. Patients ’depression and anxiety were assessed by Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Scale (HAMA) respectively before and after treatment. After 2 weeks of treatment, adverse reaction scale (TESS) was used to evaluate the patients’ Reaction conditions; and compared the clinical efficacy of both groups. Results The total effective rate in the observation group was 92.86%, which was significantly higher than that in the control group (71.43%), the difference was statistically significant (P <0.05). After treatment, the scores of HAMD and HAMA in both groups were significantly lower than those before treatment, and the scores of HAMD and HAMA in observation group were significantly lower than those in control group (P <0.05); After 4 weeks of treatment, TESS score of the control group was significantly lower, the difference was statistically significant (P <0.05). Conclusions Rose Jieyu Decoction combined with biofeedback treatment of patients with maintenance hemodialysis depression can significantly improve the depression of patients with MHD depression, improve clinical efficacy, and less side effects, can be clinically promoted.