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目的 :探讨广州市绝经后妇女维生素D受体 (VDR)基因多态性与骨密度关系。方法 :选绝经后妇女138例 ,用分子生物学技术 ,限制性内切酶片段长度多态性 (RFLP)检测VDR基因 ,用双能X线骨密度仪 (DEXA)测定其L2～4,颈、Ward’S等部位的骨密度。结果 :VDR基因BB、bb、Bb分别占5.07 %、53.63 %、41.30 % ,绝经后妇女VDR基因型发生骨质疏松 (OP)分别为 :BB占85.7 %、bb占72.8 %、Bb占63.2 % ,其中以BB型的BMD最低 ,Bb型的BMD较高。结论 :(1)VDR基因多态性与种族、居住区域不同有关。(2)VDR基因多态性可能与绝经后妇女发生OP有一定的关系。
Objective: To investigate the relationship between vitamin D receptor (VDR) gene polymorphism and bone mineral density in postmenopausal women in Guangzhou. Methods: 138 postmenopausal women were selected. VDR gene was detected by molecular biology techniques and restriction fragment length polymorphism (RFLP). The levels of L2 ~ 4, neck and neck were measured by dual energy X-ray absorptiometry (DEXA) , Ward’S and other parts of the bone density. Results: The VDR genotypes BB, bb and Bb accounted for 5.07%, 53.63% and 41.30% respectively. The postmenopausal women with osteoporosis (VDR) genotypes were: BB accounted for 85.7%, bb accounted for 72.8%, Bb accounted for 63.2% , Of which BMD was the lowest in BB type and higher in Bb type. Conclusion: (1) VDR gene polymorphism is related to race and living area. (2) VDR gene polymorphism may have a certain relationship with OP in postmenopausal women.