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我们用药掺食法培养吗啡依赖大鼠模型，研究了吗啡依赖大鼠肝线粒体自由基损伤及其结构与功能的变化。结果发现：超氧化物歧化酶（ＳＯＤ）活性明显降低、丙二醛（ＭＤＡ）含量明显升高；细胞色素Ｃ氧化酶活性、心磷脂含量和膜流动性都明显降低。这表明吗啡依赖大鼠肝线粒体自由基清除能力降低，导致自由基损伤增加，并进一步影响到线粒体的结构与功能。线粒体结构与功能的这种改变可能在吗啡诱导的肝损伤中有重要作用。
We use drug-mixed culture of morphine-dependent rat model of morphine-dependent rat liver mitochondrial free radical damage and changes in its structure and function. The results showed that the activity of superoxide dismutase (SOD) decreased significantly and the content of malondialdehyde (MDA) increased obviously. The cytochrome C oxidase activity, cardiolipin content and membrane fluidity were obviously decreased. This indicates that morphine-dependent rat liver mitochondrial free radical scavenging capacity decreased, resulting in increased free radical damage and further affect the mitochondrial structure and function. This change in mitochondrial structure and function may play an important role in morphine-induced liver injury.