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目的:分析脑动脉瘤患者行介入治疗后对比剂肾病(CIN)的相关危险因素。方法:选取2013年6月到2015年12月在广州医科大学附属第三医院行介入治疗的110例脑动脉瘤患者为研究对象,根据术后血清肌酐浓度变化情况分为对比剂肾病组(CIN组)和非对比剂肾病组(非CIN组),分析CIN相关危险因素。结果:CIN组21例,非CIN组89例。糖尿病、慢性肾功能不全、高血压病与CIN相关,其中糖尿病、慢性肾功能不全为脑动脉瘤介入治疗后发生CIN的危险因素(P<0.05)。结论:糖尿病、慢性肾功能不全是脑动脉瘤介入治疗后对比剂肾病的重要危险因素,术前应做好预防措施。
Objective: To analyze the risk factors of contrast-induced nephropathy (CIN) after interventional therapy in patients with cerebral aneurysm. Methods: A total of 110 patients with cerebral aneurysm who underwent interventional therapy in the Third Affiliated Hospital of Guangzhou Medical University from June 2013 to December 2015 were selected as the study subjects. According to the change of postoperative serum creatinine concentration, CIN Group) and non-contrast nephropathy group (non-CIN group). The risk factors related to CIN were analyzed. Results: There were 21 cases in CIN group and 89 cases in non-CIN group. Diabetes mellitus, chronic renal insufficiency and hypertension are related to CIN. Among them, diabetes mellitus and chronic renal insufficiency are the risk factors of CIN after interventional therapy of cerebral aneurysm (P <0.05). Conclusion: Diabetes mellitus and chronic renal insufficiency are important risk factors of contrast-induced nephropathy after interventional therapy of cerebral aneurysm. Precautionary measures should be taken before operation.