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目的对标准复治方案治疗北京市复治肺结核患者的疗效进行评价。方法采用回顾性调查方法,对2009—2010年全市登记管理的复治菌阳肺结核患者,根据药敏试验结果将其分为利福平敏感组(138例)和利福平耐药组(39例),每组又分为异烟肼敏感组和异烟肼耐药组,其中异烟肼、利福平均敏感组114例,异烟肼耐药、利福平敏感组24例,异烟肼敏感、利福平耐药组12例,异烟肼、利福平均耐药组27例,对其使用2HRZE(S)/6HRE标准复治化疗方案的疗效进行回顾性分析。结果异烟肼敏感组与异烟肼耐药组比较,痰菌阴转率分别为92.9%(117/126)、66.7%(34/51),治疗成功率分别为87.3%(110/126)、60.8%(31/51)。两组在痰菌阴转情况及治疗转归方面差异均无统计学意义(χ2MH值分别为2.183、1.974,PMH值均>0.05)。利福平敏感组与利福平耐药组比较,痰菌阴转率分别为94.2%(130/138)、53.8%(21/39),治疗成功率分别为88.4%(122/138)、48.7%(19/39),两组在痰菌阴转情况及治疗转归等方面差异均有统计学意义(χ2MH值分别为16.199、12.686,PMH值均<0.001)。结论利福平敏感的复治肺结核患者采用标准复治方案治疗,效果良好;对利福平耐药的复治肺结核患者采用标准复治方案治疗的合理性值得探讨,还需要进行更多的研究。
Objective To evaluate the efficacy of standard rehabilitation treatment for patients with pulmonary tuberculosis in Beijing. Methods A retrospective study was conducted to investigate the effect of rifampicin-sensitive group (138 cases) and rifampicin-resistant group (39 cases) Cases) were divided into isoniazid-sensitive group and isoniazid-resistant group, in which isoniazid and rifampicin were sensitive group, 114 cases were isoniazid resistant, 24 cases were susceptible to rifampicin, Hydrazine-sensitive, 12 cases of rifampin-resistant group, isoniazid, and the average of 17 cases of rifampicin-resistant group. The curative effect of standard regimen of 2HRZE (S) / 6HRE was retrospectively analyzed. Results The negative conversion rates of sputum in the isoniazid sensitive group and the isoniazid resistant group were 92.9% (117/126) and 66.7% (34/51), respectively. The success rates of treatment were 87.3% (110/126) , 60.8% (31/51). There was no significant difference between the two groups in sputum negative conversion and treatment outcome (χ2MH values were 2.183,1.974, PMH values were> 0.05). The sputum negative conversion rates were 94.2% (130/138) and 53.8% (21/39) in the rifampin-sensitive group and the rifampicin-resistant group, respectively, and the success rates were 88.4% (122/138) 48.7% (19/39) respectively. There were significant differences between the two groups in sputum negative conversion and treatment outcome (χ2MH values were 16.199 and 12.686, respectively, PMH values were <0.001). Conclusions Rifampicin-sensitive re-treatment of pulmonary tuberculosis patients treated with standard regimen, with good results; the rationality of standard regimen in patients with re-treatment of rifampicin-resistant re-treatment of tuberculosis is worth discussing, but more research is needed .