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目的制备和厚朴酚环糊精纳米海绵,考察环糊精纳米海绵对和厚朴酚的增溶作用,并对其理化性质进行初步考察。方法采用β-环糊精与碳酸二苯酯合成环糊精纳米海绵,并用红外光谱法(FT-IR)和热分析法(DSC)进行验证。结果和厚朴酚环糊精纳米海绵在DSC中无和厚朴酚的特征吸收峰,FT-IR中1 780 cm~(-1)左右出现新的羰基峰。体外释放实验中和厚朴酚环糊精纳米海绵5 h的累积释放为88.57%,而和厚朴酚混悬液仅为46.55%。纳米海绵使和厚朴酚在水中的溶解度增加了8.87倍。结论成功制备了和厚朴酚环糊精纳米海绵,显著提高了和厚朴酚的溶解度。
OBJECTIVE To prepare honokiol cyclodextrin nanoshells and investigate the solubilization of honokiol with cyclodextrin nanoshells. The physical and chemical properties of honokiol were also investigated. Methods β-Cyclodextrin and diphenyl carbonate were used to synthesize cyclodextrin nanoshells. The results were confirmed by infrared spectroscopy (FT-IR) and thermal analysis (DSC). Results Honokiol cyclodextrin nanospond had no characteristic absorption of honokiol in DSC, and a new carbonyl peak appeared at around 1 780 cm -1 in FT-IR. In vitro release experiments, the cumulative release of honokiol cyclodextrin nanoe sponge for 5 h was 88.57%, while that of honokiol suspension was only 46.55%. Nano sponge increased the solubility of honokiol in water by 8.87 times. Conclusion The honokiol cyclodextrin nano-sponge was successfully prepared, which significantly enhanced the solubility of honokiol.