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目的：建立保留交感神经的高选择性迷走神经切断术（ＨＳＶ－ＡＰ）的动物实验模型。方法：６０只雄性ＳＤ大鼠随机分为三组：ＨＳＶ－ＡＰ组、ＨＳＶ组和正常对照组（Ｃ组），每组２０只。结果：ＨＳＶ－ＡＰ术后胃壁泌酸区交感神经分布密度与Ｃ组比较，下降不显著，去甲肾上腺素含量与Ｃ组无差别（７４５．０±４０８．９ＶＳ８９９．６±２３５．１，Ｐ＞０．０５）。而ＨＳＶ术后胃部泌酸区交感神经分布密度显著下降，去甲肾上腺素含量低于ＨＳＶ－ＡＰ术后（２９３．０±２１４．８ＶＳ７４５．８±４０８．９，Ｐ＜０．０１）。ＨＳＶ－ＡＰ术后胃体部迷走神经追踪脑干内未见标记细胞，而胃窦部迷走神经追踪脑干内可见标记细胞。结论：本试验证实采用保留胃小弯血管的ＨＳＶ—ＨＳＶ－ＡＰ术式，既可完整切断支配胃部泌酸区的迷走神经，又可保留交感神经。
Objective: To establish an animal model of high selective vagotomy (HSV-AP) that preserves the sympathetic nerve. Methods: Sixty male Sprague-Dawley rats were randomly divided into three groups: HSV-AP group, HSV group and normal control group (C group), with 20 rats in each group. Results: The density of sympathetic nerves in gastric acid secretion zone in HSV-AP group was not significantly decreased compared with that in C group (n = 745.0 ± 408.9 vs 789.6 ± 235.1, P > 0.05). After HSV, the density of sympathetic nerve in gastric acid district significantly decreased, and the content of norepinephrine was lower than that of HSV-AP (293.0 ± 214.8 VS745.8 ± 408.9, P <0.01). There was no labeled cells in the vagus nerve of HSV-AP after gastric vagus tracking in the brainstem, while the labeled cells were observed in the vagus nerve of the gastric antrum following the brainstem. CONCLUSIONS: This study confirms the use of HSV-HSV-AP technique to preserve the gastric lesser vascular vessel, which can both completely sever the vagus nerves that control the gastric acid secretion area and retain the sympathetic nerve.