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目的探讨高通量透析对糖尿病肾病(尿毒症期)患者炎症因子的影响。方法选择于该院进行血液透析的糖尿病肾病维持血液透析患者90例,共有85例患者完成此次研究,其中观察组43例,对照组42例。在基础治疗的基础上,分别给予高通量透析和低通量透析,1个月后对比治疗前后的BMI、血压、贫血情况、高敏C-反应蛋白(hs-CRP)、胞介素-6(IL-6)和人肿瘤坏死因子-α(TNF-α)变化。结果二组患者治疗前后的BMI、血压以及贫血情况差异均无统计学意义(P>0.05);但观察组患者hs-CRP、IL-6以及TNF-α水平较治疗前均有显著性下降(P<0.01),差异具有统计学意义,而对照组患者hsCRP治疗前后未见明显变化(P>0.05),但血清IL-6以及TNF-α水平较治疗前显著性下降(P<0.05),但下降幅度未及观察组,差异具有统计学意义。结论高通量透析可以更好的清除患者体内炎症因子,对预防患者心血管事件可能会有一定的帮助。
Objective To investigate the effects of high-flux dialysis on inflammatory cytokines in patients with diabetic nephropathy (uremia). Methods 90 cases of diabetic hemodialysis patients with hemodialysis were enrolled in this study. A total of 85 patients completed the study, 43 in the observation group and 42 in the control group. On the basis of basic treatment, high-dose dialysis and low-dose dialysis were given respectively. One month later, BMI, blood pressure, anemia, hs-CRP, (IL-6) and human tumor necrosis factor-α (TNF-α) changes. Results There were no significant differences in BMI, blood pressure and anemia between the two groups before and after treatment (P> 0.05). However, the levels of hs-CRP, IL-6 and TNF-α in the observation group were significantly lower than those before treatment (P <0.01). There was significant difference between the two groups (P> 0.05), but there was no significant change in the control group before and after hsCRP treatment (P> 0.05), but the level of serum IL-6 and TNF- However, the drop was not as good as the observation group, the difference was statistically significant. Conclusion High-throughput dialysis can better clear the inflammatory cytokines in patients and may be helpful to prevent cardiovascular events in patients.