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抗-HBe阳性的乙型肝炎病毒(HBV)携带者包括无症状携带者(ASCs)和慢性活动性肝炎(CAH)病人,前者HBV复制水平低,而后者高。为研究X基因突变是否为抗-HBe阳性的ASCs和CAH病人HBV不同复制水平的原因,作者用PCR方法对下列人群血清中HBV颗粒的X基因进行扩增和测序,同时检测其前C区基因。 受试者:19例抗-HBe阳性ASCs,其血清HBsAg阳性,长期随访丙氨酸转氨酶(ALT)正常,未接受任何特殊治疗;9例抗-HBe阳性CAH病人处于肝炎活动期,血
Anti-HBe positive Hepatitis B virus (HBV) carriers include asymptomatic carriers (ASCs) and chronic active hepatitis (CAH) patients, the former HBV replication is low, while the latter is high. In order to study whether X mutation is an anti-HBe-positive ASCs and CAH patients with different levels of replication of HBV, the authors used PCR to amplify and sequence the X-gene of HBV particles in the serum of the following people and detect the pre-C-region gene . Subjects: Nineteen anti-HBe positive ASCs were positive for serum HBsAg. Long-term follow-up of alanine aminotransferase (ALT) was normal and did not receive any special treatment. Nine anti-HBe-positive CAH patients were in active hepatitis and blood