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腺病毒介导ＨＳＶ－ｔｋ基因结合ＧＣＶ治疗能有效地治疗脑肿瘤［１，２］，目前应用的腺病毒载体在野生型病毒感染或宿主细胞中存在Ｅ１区序列提供反式激活的条件下，有产生野生型或有复制能力的回变病毒（ＲＣＡ）的可能性。另外，在腺病毒载体原位注射治疗肿瘤的过程中，是
Adenovirus-mediated HSV-tk gene therapy combined with GCV can effectively treat brain tumors [1, 2]. The currently used adenovirus vectors, under conditions of wild-type virus infection or the presence of E1 region sequences in host cells that provide transactivation, There is the possibility of producing wild-type or replication-competent retrovirus (RCA). In addition, adenovirus in situ injection in the treatment of cancer in the process