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从1988年11月～1989年2月,我们在三省六县调查了14809名新生儿,其中有100例新生儿硬肿症,占6.7‰;34例患儿死亡,病死率占34％。硬肿发生日龄平均为5.9天,早产儿、SGA和体重<2500g新生儿发病较早,平均为4～5天。足月儿或体重≥2500g者发病平均为7天(P<0.05)。硬肿部位以大腿、臀部、面颊、上肢和躯干明显。39例患儿的硬肿面积>50％。常见的症状是皮肤发硬和水肿、皮色紫红、反应低下、拒奶、体温不升。硬肿症病死率与硬肿面积密切相关,>50％者为53.8％,<50％者为21.3％。
From November 1988 to February 1989, we surveyed 14,809 newborns in six provinces and three counties, of which 100 were newborn with scleredema (6.7%); 34 patients died and the fatality rate was 34%. Scleroderma average age of 5.9 days, premature children, SGA and body weight <2500g neonatal morbidity earlier, with an average of 4 to 5 days. Full-term children or those with a body weight ≥ 2500g had an average onset of 7 days (P <0.05). Sclerosis site to the thigh, buttocks, cheeks, upper limbs and trunk obvious. 39 cases of children with edema area> 50%. Common symptoms are hard and edematous skin, skin color purple, reaction is low, refused to milk, body temperature does not rise. Scleroderma mortality and edema area are closely related,> 50% were 53.8%, <50% were 21.3%.