论文部分内容阅读
原发性醛固酮增多症是难治性高血压的一个常见原因。醛固酮合成酶(aldosterone synthase,AS,由CYP11B2基因编码)在肾上腺合成醛固酮。AS与负责皮质醇生成的11β-羟化酶(由CYP11B1基因编码)有93%同源性。此同源性阻碍了原发性醛固酮增多症的新治疗药物(可选择性抑制醛固酮但不影响皮质
Primary aldosteronism is a common cause of refractory hypertension. Aldosterone synthase (AS, encoded by the CYP11B2 gene) synthesizes aldosterone in the adrenal glands. The AS is 93% homologous to 11β-hydroxylase responsible for cortisol production (encoded by the CYP11B1 gene). This homology hinders the development of new therapies for primary aldosteronism (which selectively inhibit aldosterone but do not affect the cortex