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安莎美登素(Ansamitocin)是一种由奴卡氏菌(Nocardia)SP.No.C—15003(N—1)产生的新的抗肿瘤抗生素。它是一种含有五种组份的混合物。其中组份 C—15003 P—1和 P—2经鉴别分别是 Maytanacine 与 Maytancinolpropionate。而组份 C—15003 P—3,P—3’和 P—4则是新的抗肿瘤抗生素。安莎美登素的分离是将发酵液在 pH7.0提入醋酸乙脂,浓缩至少量体积之后,加10倍量的石油醚沉出油状物。将油状物
Ansamitocin is a new antitumor antibiotic produced by Nocardia SP. No. C-15003 (N-1). It is a mixture of five components. Among them, components C-15003 P-1 and P-2 were identified as Maytanacine and Maytancinolpropionate, respectively. Components C-15003 P-3, P-3 ’and P-4 are new antitumor antibiotics. The separation of the maytansinoids is that the fermentation broth is introduced into ethyl acetate at a pH of 7.0, concentrated to a minimum volume, and then 10 times the amount of petroleum ether is added to precipitate the oil. The oil