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目的观察高压氧对病毒性脑炎患儿免疫功能及预后的影响。方法选择2004年7月至2007年6月山东沂水中心医院收治的100例病毒性脑炎患儿,随机分成高压氧治疗组50例,无高压氧治疗对照组50例,同时设正常组50例。记录两组症状、体征变化,2周后脑电图变化,随访3个月记录后遗症状,两组治疗前后分别检测CD4+、CD8+、CD4+/CD8+、IgG、IgM、IgA。结果与对照组相比,治疗组症状、体征、2周后脑电图恢复加快(P<0.01或P<0.05),后遗症状中间歇性头痛、记忆力下降者减少(P<0.05),治疗后治疗组较对照组、正常组CD4+、CD8+、CD4+/CD8+、IgG、IgM均下降(P<0.05)。结论高压氧能缩短病毒性脑炎患儿病程,减少后遗症状,但可引起患儿免疫功能抑制。
Objective To observe the effects of hyperbaric oxygen on immune function and prognosis in children with viral encephalitis. Methods A total of 100 children with viral encephalitis who were treated in Shandong Yishui Central Hospital from July 2004 to June 2007 were randomly divided into hyperbaric oxygen therapy group (n = 50) and hyperbaric oxygen therapy control group (n = 50) example. Two groups of symptoms and signs were recorded. Changes of EEG after 2 weeks and post-symptom of 3 months were recorded. CD4 +, CD8 +, CD4 + / CD8 +, IgG, IgM and IgA were detected before and after treatment in both groups. Results Compared with the control group, the symptoms and signs of the treatment group were improved after 2 weeks (P <0.01 or P <0.05), and those with sequelae of intermittent headache and memory loss decreased (P <0.05) Compared with the control group, the levels of CD4 +, CD8 +, CD4 + / CD8 +, IgG and IgM in the normal group decreased (P <0.05). Conclusion Hyperbaric oxygen can shorten the course of children with viral encephalitis and reduce the symptoms, but can cause immune suppression in children.