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细胞因子IL 1 ,IL 2 ,IL 6及TNF在睡眠过程中具有一定的昼夜节律性 ,它们能不同程度地促进睡眠 ,IL 1 ,TNF能协同作用调节睡眠 ,用其拮抗剂均能减弱催眠功能 ,脑内的催眠因子能通过脑脊液给外周传递信息。另外 ,睡眠的调节还有IL 4 ,IL 1 0 ,GABA等参与。在异常性睡眠中这些因子均发生相应节律性改变呈显著升高趋势 ,它们的改变能介导机体内分泌功能的紊乱 ,使生物体免疫功能降低 ,导致生理功能受损。提示细胞因子是睡眠的重要调节因子之一。
Cytokines IL 1, IL 2, IL 6 and TNF have certain circadian rhythms during sleep. They can promote sleep to some extent. IL 1 and TNF can cooperate to regulate sleep, and their antagonists can reduce the hypnotic function , The hypnotic factor in the brain can transmit information to the periphery through cerebrospinal fluid. In addition, the regulation of sleep IL 4, IL 1 0, GABA and other participation. All of these factors in abnormal sleep are significantly increased rhythmicity trend, their changes can mediate the disorder of endocrine function, reduce the immune function of organisms, leading to impaired physiological function. It is suggested that cytokines are one of the important regulators of sleep.