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目的探讨血管紧张素转换酶抑制剂（ＡＣＥＩ）—洛汀新对各种慢性肾功能不全患者肾功能的保护作用。方法对１１４例慢性肾功能不全患者进行前瞻性分析研究，其中洛汀新治疗组５８例，美多心安对照组５６例，试验的终点定义为肾小球滤过率（ＧＦＲ）降低到基础值的５０％或需要透析治疗时的水平。结果治疗３年治疗组９％患者达到终点，显著低于对照组的２３％（Ｐ＜００５）；治疗组ＧＦＲ减退速率平均为（５８８±３１０）ｍｌ·ｍｉｎ１·ｙｒ１，显著低于对照组的（８６０±３３０）ｍｌ·ｍｉｎ１·ｙｒ１（Ｐ＜００１）。分析显示洛汀新对轻度肾功能不全患者的疗效最好，对肾小球性疾病、糖尿病肾病肾功能具有保护作用，对慢性间质性肾炎、多囊肾、痛风性肾病效果不明显。结论洛汀新对慢性肾功能衰竭患者的肾功能具有保护作用。
Objective To investigate the protective effect of angiotensin converting enzyme inhibitor (ACEI) - Lotensin on renal function in patients with chronic renal failure. Methods A total of 114 patients with chronic renal failure were prospectively studied. Among them, 58 patients in the Lotensin treatment group and 56 patients in the Metoprolol control group were defined as the reduction of glomerular filtration rate (GFR) to the baseline value 50% or need dialysis treatment level. Results In the 3-year treatment group, 9% of the patients reached the end point, which was significantly lower than that of the control group (23%, P <005). The mean GFR decrease rate in the treatment group was (588 ± 310) ml · min -1 yr 1, significantly lower than the control group (8 60 ± 3 30) ml · min 1 · yr 1 (P <0 01). Analysis showed that Lotensin in patients with mild renal insufficiency the best effect on glomerular disease, diabetic nephropathy renal function has a protective effect on chronic interstitial nephritis, polycystic kidney disease, gouty nephropathy effect is not obvious. Conclusion Lotensin has a protective effect on renal function in patients with chronic renal failure.