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随着机械化兵员运输和旅游业的发展,运动病的发生已出现增多趋势。运动病是一种人在乘坐运动物体时而发生的暂时性的剧烈前庭功能紊乱性疾病。主要症状有头晕、恶心、呕吐、出冷汗等。目前防治药物种类很多,其中东莨菪碱是最有效的一种。过去采用的肌肉注射或口服的给药方式,由于血药浓度的峰谷变化而常引起疲劳、口干、视力模糊的副作用,甚至产生精神错乱及幻视等毒性反应。国外70年代首先推出了达到这种要求的透皮给药系统(TTS—Scopolamine)。我院经过一年零七个月的努力,于1987年10月研制成功膜控释型东莨
With the development of mechanized soldier transportation and tourism, the incidence of sports diseases has increased. Motion sickness is a transient, severe vestibular dysfunction disorder that occurs when a person rides a sports object. The main symptoms are dizziness, nausea, vomiting, cold sweats and so on. At present, there are many types of drugs for prevention and treatment, of which scopolamine is the most effective one. Intramuscular or oral administration methods used in the past often caused fatigue, dry mouth, blurred vision, side effects, and even toxic effects such as mental confusion and visual hallucinations due to changes in the peak-to-valley concentration of blood drug. In the 1970s abroad, the TPS-Scopolamine system was first introduced. After one year and seven months of hard work in our hospital, in October 1987, we successfully developed a membrane-controlled release formula.