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目的 探讨低剂量类固醇吸入加低剂量茶碱口服对轻～中度哮喘病人临床症状、肺功能与气道反应性的影响。方法 Ａ 组２１ 例给予二丙酸培氯松（ＢＤＰ）吸入３００ μｇ／ｄ、加缓释放茶碱片口服２００ ｍｇ／ｄ；Ｂ组２２ 例给予ＢＤＰ吸入６００ μｇ／ｄ， 疗程１３ 周。结果 两组患者的临床症状、第１ 秒用力肺容积（ＦＥＶ１） 及ＦＥＶ１／用力肺活量（ＦＶＣ） 、呼气峰流速值（ＰＥＦ） 及其变异率（ＰＥＦＲ） 和气道反应性（ＰＤ２０） 有显著改善，Ａ组的２５ ％ ～７５％ 、５０％ 及７５％ 用力呼气流速（ＦＥＦ２５％ ～７５％ 、ＦＥＦ５０％ 及ＦＥＦ７５％） 在治疗后均有显著升高， 而Ｂ组则无明显升高。结论 低剂量类固醇吸入配合低剂量茶碱口服与单纯较高剂量类固醇吸入均可改善轻～中度哮喘患者的临床症状、肺功能及气道反应性， 而前者可更有效地改善气道功能。
Objective To investigate the effects of low dose steroid inhalation combined with low dosage of theophylline on clinical symptoms, lung function and airway responsiveness in patients with mild to moderate asthma. In group A, 21 cases were given 300 μg / d of BDP and 200 mg / d of sustained-release theophylline. B group received 22 μg of BDP 600 μg / d for 13 weeks. Results The clinical symptoms, FEV 1, FEV 1 / FVC, PEF and PD 20 in both groups were significant (25% -75%, 50%, and 75% forced expiratory flow rate (FEF25% -75%, FEF50% and FEF75%) in group A were significantly increased after treatment, while those in group B were not significantly higher . Conclusion Low dose steroid inhalation combined with low dosage of theophylline and inhalation of higher dose of steroid alone can improve clinical symptoms, pulmonary function and airway responsiveness in patients with mild to moderate asthma, while the former can improve airway function more effectively.