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目的比较晚期舌鳞癌不同治疗手段的疗效并探讨影响其预后的因素。方法回顾性分析cTNM晚期舌鳞癌92例的临床及随访资料,Kaplan-Meier法计算累计生存率,Cox回归模型进行多因素分析。结果全组3年、5年生存率分别为52.40%、37.23%。单因素分析显示,单纯化疗和诱导化疗后放疗两组与单纯手术、诱导化疗后手术、手术后放疗3组间的累计生存率间差异有统计学意义;多因素分析显示cTNM分期、原发灶手术、局部区域复发是影响预后的独立因素。结论cTNM分期、原发灶手术、局部区域复发是影响晚期舌鳞癌预后的独立因素;对其行手术治疗或包含手术的综合治疗可以获得相对好的疗效,单纯化疗或化疗后放疗疗效差。
Objective To compare the curative effects of different treatment of advanced tongue squamous cell carcinoma and to explore the factors that influence its prognosis. Methods The clinical and follow-up data of 92 patients with advanced tongue cancer of cTNM were retrospectively analyzed. The cumulative survival rate was calculated by Kaplan-Meier method and multivariate analysis was performed by Cox regression model. Results The 3-year and 5-year survival rates of the whole group were 52.40% and 37.23% respectively. Univariate analysis showed that there was significant difference between the two groups in the chemotherapy alone and the chemotherapy-induced chemoradiotherapy and the survival rates in the three groups after surgery, chemotherapy alone, and postoperative radiotherapy. Multivariate analysis showed that cTNM staging, primary tumor Surgery, local regional recurrence is an independent factor affecting the prognosis. Conclusions cTNM staging, primary tumor surgery and local regional recurrence are independent factors that affect the prognosis of advanced tongue squamous cell carcinoma. Relatively good curative effect can be obtained for the patients who underwent surgical treatment or include surgery. The curative effect of radiotherapy alone or chemotherapy is poor.