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目的 应用高分辨率相位差增强成像(PADRE)技术研究正常成人Gennari纹的显示情况,并测算初级视觉皮质的相位值,探讨利用PADRE技术研究活体大脑皮质纤维构筑的可行性.方法 采用3.0TMR对36名健康志愿者枕叶行高分辨率PADRE技术成像,对相位增强(Padre)、组织增强(TE)及血管增强(VE)3种重建模式图像上Gennari纹的显示情况分别进行评分,并测算初级视觉皮质的相位值.统计学分析分别采用Wilcoxon符号秩和检验和配对t检验.结果 PADRE技术可清晰显示36名健康志愿者Gennari纹,表现为与初级视觉皮质表面平行的低信号带,Padre、TE及VE图像Gennari纹平均评分值分别为2.81±0.39、1.76±0.44、1.81±0.39,三者之间比较差异具有统计学意义,Padre对Gennari纹的显示优于TE和VE(Z值分别为-13.376、-13.843,P值均＜0.01),左、右侧初级视觉皮质的相位值分别为0.210±0.087、0.214±0.079,两者间差异无统计学意义(t=-0.265,P＞0.05).结论 高分辨率PADRE技术可以显示活体Gennari纹,为研究活体大脑皮质区纤维构筑与皮质区功能的相关性提供了一种新方法.“,”Objective To assess the delineations of the stria of Gennari in healthy adults using phase-difference enhanced imaging (PADRE) technique and measure the phase values in striate cortex,discussing the feasibility of studying myeloarchitecture of human cortex in vivo using PADRE technique.Methods High-resolution PADRE raw images covering the occipital lobes were acquired from thirty-six healthy volunteers using a 3.0 T MR system.Padre,tissue enhancement (TE) and vessel enhancement(VE) images were reconstructed and the delineations of the stria of Gennari on these images were scored respectively.The phase values of striate cortex were detected and calculated.Wilcoxon tests and paired t tests were used.Results In all 36 healthy subjects,the stria of Gennari were depicted as hypointense bands parallel to the surface of primary visual cortex in PADRE images.The mean scores were 2.81 ± 0.39,1.76 ± 0.44 and 1.81 ± 0.39 in Padre,TE and VE images,respectively,which demonstrated significant differences,Padre images were superior to TE images as well as VE images in delineating the stria of Gennari (Z =-13.376、-13.843,P ＜0.01).Phase values of the striate cortex in the left and right side were 0.210 ± 0.087,0.214 ± 0.079 radians respectively,and there was no statistical difference (t =-0.265,P ＞0.05).Conclusion The PADRE technique can identify the stria of Gennari in vivo,which may provide a novel tool for the investigation of myeloarchitecture in different cortical areas to establish correspondence between the anatomical and functional specialization in vivo.