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目的:比较七叶皂苷 钠与甘露醇治疗出血后脑水肿的疗效。方法:40例经头颅CT证实的脑出血后脑水肿病人按出血量分为小量出血组及中量出血组,每组又随机分为甘露醇对照组(小量及中量出血组各10例,小量出血组用量为25g/d;中等量出血用量为25×2g/d,分12h给药一次),七叶皂苷钠治疗组(小量及中量出血组各10例,小量出血用量为20 mg/d;中等量出血用为20 mg/d合并用甘露醇25g/d,分12h间隔给药1次)。七叶皂苷钠均为20 mg溶于500 ml生理盐水静滴。结果:七叶皂苷钠治疗组与甘露醇对照组CT所示水肿吸收率无明显差异(P>0.050)。但肾功能损害发生率低。结论:七叶皂苷钠治疗出血后脑水肿有效,且与甘露醇疗效无明显差异,但肾功能损害发生率低。
Objective: To compare the therapeutic effect of sodium aescinate and mannitol on cerebral edema after hemorrhage. Methods: 40 cases of brain edema after cerebral hemorrhage confirmed by skull CT were divided into small bleeding group and moderate bleeding group according to the amount of bleeding, each group were randomly divided into mannitol control group (small and medium amount of bleeding group 10 cases , A small amount of bleeding group was 25g / d; a moderate amount of bleeding 25 × 2g / d, administered once 12h), sodium aescinate treatment group (small and moderate bleeding group 10 cases, a small amount of bleeding Dosage of 20 mg / d; moderate bleeding with 20 mg / d combined with mannitol 25g / d, administered once every 12h intervals). Sodium aescinate are 20 mg dissolved in 500 ml of normal saline intravenous infusion. Results: There was no significant difference in edema absorption rate between CTX and mannitol control group (P> 0.050). However, the incidence of renal damage is low. Conclusion: Sodium aescinate is effective in treating cerebral edema after hemorrhage, and there is no significant difference between the two drugs and mannitol, but the incidence of renal dysfunction is low.