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目的:探讨三藤通痹丸治疗类风湿性关节炎对血小板相关参数和急性时相反应物水平的影响。方法:将2010年4月~2013年4月收治的活动性类风湿性关节炎患者110例,随机分为2组各55例。2组均予相关基础治疗,观察组加服三藤通痹丸治疗;对照组加服正清风痛宁片治疗,观察2组患者临床治疗效果及治疗前后血小板相关参数和急性时相反应物水平变化。结果:治疗后,总有效率观察组为89.09%,对照组为70.90%,2组比较,差异有显著性意义(P<0.05)。治疗后2组血小板相关参数均较治疗前下降,差异均有显著性意义(P<0.05),且观察组总体水平优于对照组(P<0.05)。2组治疗前血沉、C-反应蛋白均高于正常水平,治疗后下降,且观察组下降幅度大于对照组,差异均有显著性意义(P<0.05)。结论:三藤通痹丸治疗类风湿性关节炎效果显著,可有效抑制急性时相反应物释放,降低血小板相关参数。
Objective: To investigate the effect of three tofu tongbi pill on rheumatoid arthritis (platelet) related parameters and acute phase reactant level. Methods: One hundred and ten patients with active rheumatoid arthritis who were admitted from April 2010 to April 2013 were randomly divided into two groups of 55 cases each. The two groups were given the relevant basic treatment, the observation group plus three Tuteng Tongbi treatment; the control group plus serving Zhengqing Fengtongning treatment, two groups of patients with clinical treatment and before and after treatment platelet-related parameters and acute phase reactant levels Variety. Results: After treatment, the total effective rate was 89.09% in the observation group and 70.90% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the relative parameters of platelets in both groups were significantly lower than those before treatment (P <0.05), and the overall level of the observation group was better than that of the control group (P <0.05). The levels of ESR and C-reactive protein in the two groups before treatment were both higher than normal and decreased after treatment, and the decrease in observation group was greater than that in control group (P <0.05). CONCLUSIONS: Sutu Tongbi Pill is effective in treating rheumatoid arthritis, which can effectively inhibit the release of acute phase reactants and reduce the relevant parameters of platelets.