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[目的]探讨生长抑素(SS)在胃黏膜上皮癌发生、发展中的作用及地位,从而为胃癌的诊断、治疗及预后判断提供一个新的途径。[方法]应用免疫组化SABC(Strept Avidin Biotin Complex)法检测78例胃癌组织和20例正常胃黏膜、53例胃黏膜上皮各级癌前病变标本中SS的表达。[结果]SS在正常胃黏膜中阳性表达率为85.0%,癌前病变组织中阳性表达率为43.4%,胃癌组织中阳性表达率为24.3%;高/中分化组和低分化组中的阳性表达率分别为34.2%、13.5%,随分化程度减低呈下降趋势;浸润黏膜层或黏膜下层和浸润肌层或浆膜层两组的阳性表达率分别为64.3%、15.6%,随浸润程度的加深其阳性表达率呈下降趋势;无淋巴结转移组和有淋巴结转移组的阳性表达率分别为38.7%、14.9%;TNMⅠ~Ⅱ期和Ⅲ~Ⅳ期的阳性表达率分别为45.5%、8.9%。以上两组间比较差异均有统计学意义(P<0.05)。[结论]SS的低表达与胃癌的组织学分级、浸润深度、淋巴结转移及TNM分期密切相关。SS的失表达可能是胃黏膜上皮癌变过程中的重要机制之一。
[Objective] To explore the role and status of somatostatin (SS) in the occurrence and development of gastric epithelial carcinoma, so as to provide a new approach for the diagnosis, treatment and prognosis of gastric cancer. [Methods] The expression of SS in 78 specimens of gastric carcinoma, 20 specimens of normal gastric mucosa and 53 specimens of gastric precancerous lesions were detected by immunohistochemical SABC (Strept Avidin Biotin Complex) method. [Results] The positive rate of SS in normal gastric mucosa was 85.0%, the positive rate in precancerous tissue was 43.4%, and the positive rate in gastric cancer was 24.3%; positive in high/medium differentiation group and poorly differentiated group. The expression rates were 34.2% and 13.5%, respectively, and decreased with the degree of differentiation. The positive expression rates of the infiltrative mucosa or submucosa and the infiltration muscle layer or serosal layer were 64.3% and 15.6%, respectively, with the degree of infiltration. The positive expression rate of deepening showed a decreasing trend; the positive rates of lymph node metastasis and lymph node metastasis were 38.7% and 14.9%, respectively; the positive rates of TNMI-II and III-IV were 45.5% and 8.9%, respectively. . There was a statistically significant difference between the above two groups (P<0.05). [Conclusion] The low expression of SS is closely related to the histological grade, infiltration depth, lymph node metastasis and TNM staging of gastric cancer. Loss of expression of SS may be one of the important mechanisms in the carcinogenesis of gastric epithelium.