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目的探讨健康志愿者献血400 m L后血液免疫学指标质量时序变化及恢复情况。方法检测168名适龄健康无偿献血自愿者献血前、献血后即刻、献血后1d、1周、4周和男性12周、女性16周的静脉血相关指标动态变化。结果除了Ig M在献血前后无明显改变外,其他免疫学指标呈现了不同的变化趋势。首先下降的是白细胞计数和补体C3,Ig G在其他指标回升时开始下降。各指标至献血后第4周均恢复到献血前水平,但男性在献血后12周、女性16周Ig A突然出现显著下降,而补体C3却显著上升。结论献血400 m L后免疫学指标呈现交替变化,并有明显的互补效应。
Objective To investigate the timing and quality of blood immunological indices after blood donation of 400 m L in healthy volunteers. Methods The blood samples were collected from 168 voluntary blood donation volunteers before blood donation, immediately after blood donation, and after 1, 1, 4 weeks of blood donation and 16 weeks of men and 16 weeks of female volunteers. Results In addition to Ig M before and after blood donation did not change significantly, the other immunological indicators showed a different trend. The first drop is the white blood cell count and complement C3, Ig G begins to decline when other indicators pick up. Each index returned to pre-blood donation level 4 weeks after blood donation. However, at 12 weeks after blood donation, a sudden drop in IgA was observed at 16 weeks and a significant increase was observed in complement C3. Conclusion The immunological indexes of blood donated 400 m L showed alternating changes with obvious complementary effect.