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目的探讨高原缺氧对机体免疫功能及其免疫调节功能的影响。方法采用流式细胞术对高海拔地区(4 500 m)52名健康汉族人群和35名健康藏族人群进行了淋巴细胞亚群CD4+、CD8+、CD3-CD19+(B细胞)、CD3-CD56+(NK细胞)测定,并与中度海拔(西宁)地区45名健康汉族人群进行了比较。结果 2个海拔的CD4+、CD8+、CD3-CD19+、CD3-CD56+各项中,4 500 m人群CD8+高于西宁组,CD4+明显低于西宁组,P<0.05;CD19+(B细胞)西宁组高于高海拔组,P<0.05;海拔4 500 m汉族、世居藏族人群的CD4+、CD8+无统计学意义比较,P>0.05;CD3-CD56+(NK)藏族低于汉族,P<0.05;CD3-CD19+(B细胞)藏族高于汉族,P<0.05。结论高原低氧环境影响机体的免疫调节功能。
Objective To investigate the effects of plateau hypoxia on immune function and immunoregulatory function. Methods The expressions of CD4 +, CD8 +, CD3-CD19 + (B cells), CD3-CD56 + (NK cells) in 52 healthy Han population and 35 healthy Tibetan population in high altitude area (4 500 m) ) Were measured and compared with 45 healthy Han Chinese population in moderate altitude (Xining) area. Results The CD8 + T cell counts of 4 500 m population were significantly higher in the two altitudes than those in the Xining group (P <0.05), while those in the Xining group were significantly higher than those in the Xining group CD3-CD56 + (NK) Tibetan population was lower than Han nationality, P <0.05; CD3-CD19 + NK population was lower than that of Han nationality (P <0.05); There was no significant difference in CD4 +, CD8 + (B cells) Tibetan is higher than Han, P <0.05. Conclusion The plateau hypoxia environment affects the immune regulation function of the body.