Chemoattractive capacity of different lengths of nerve fragments bridging regeneration chambers for

• 作 者: Jiren Zhang Yubo Wang Jincheng Zhang
• 机 构: Department of Hand Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2012年29期
• 关键词: nerve fragment length nerve regeneration chamber bridging long nerve defect chem

A preliminary study by our research group showed that 6-mm-long regeneration chamber bridging is equivalent to autologous nerve transplantation for the repair of 12-mm nerve defects.In this study,we compared the efficacy of different lengths (6,8,10 mm) of nerve fragments bridging 6-mm regeneration chambers for the repair of 12-mm-long nerve defects.At 16 weeks after the regeneration chamber was implanted,the number,diameter and myelin sheath thickness of the regenerated nerve fibers,as well as the conduction velocity of the sciatic nerve and gastrocnemius muscle wet weight ratio,were similar to that observed with autologous nerve transplantation.Our results demonstrate that 6-,8-and 10-mm-long nerve fragments bridging 6-mm regeneration chambers effectively repair 12-mm-long nerve defects.Because the chemoattractive capacity is not affected by the length of the nerve fragment,we suggest adopting 6-mm-long nerve fragments for the repair of peripheral nerve defects.