原发性甲状腺功能减退症血脂和心肌酶谱的变化

• 作 者: 周珈莉 罗平 和惠云
• 机 构: 昆明市第一人民医院内分泌科,云南省中西医结合医院内科,
• 出 处: 实用糖尿病杂志
• 发表日期: 2011年01期
• 关键词: 原发性甲状腺功能减退(甲减) 左旋甲状腺素治疗 血脂 甲状腺功能

原发性甲减患者40例,在诊断初和经左旋甲状腺素治疗4～12周后,分别测定空腹血清FT3、FT4、TSH、总胆固醇(TC)、甘油三酯(TG)、门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)及其同工酶(CK—MB)、乳酸脱氢酶。结果甲减可致血脂、心肌酶谱显著增高,优甲乐替代治疗12周后,甲状腺功能恢复正常,TC、LDL—C、心肌酶谱均明显下降。结论原发性甲减患者应用左旋甲状腺素治疗可显著降低TC、LDL—C、心肌酶谱水平。

Forty patients with primary hypothyroidism were enrolled in this study. Fasting serum FT3, FT4, TSH, total cholesterol (TC), triglyceride (TG), aspartate Acid aminotransferase (AST), creatine kinase (CK) and its isoenzyme (CK-MB), lactate dehydrogenase. Results hypothyroidism can cause blood lipids, myocardial zymogram was significantly higher, Euthyrox replacement therapy after 12 weeks, thyroid function returned to normal, TC, LDL-C, myocardial enzymes were significantly decreased. Conclusion Primary hypothyroidism in patients with levothyroxine treatment can significantly reduce TC, LDL-C, myocardial enzyme level.