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目的：通过比较奥美拉唑＋醋氨己酸锌与奥美拉唑＋安慰剂治疗胃及十二指肠溃疡的溃疡愈合率和Ｓ２获得率来评价醋氨己酸锌对提高溃疡愈合质量的作用。方法：本研究采用双盲单模拟的多中心临床研究，将内镜证实的胃溃疡６１例，十二指肠溃疡７５例随机分成试验组（奥美拉唑＋醋氨己酸锌）和对照组（奥美拉唑＋安慰剂），剂量为奥美拉唑２０ｍｇ，ｑｄ，醋氨基酸锌３００ｍｇ，ｔｉｄ；疗程：十二指肠溃疡治疗４周；胃溃疡６周。结果：溃疡愈合率：胃溃疡试验组和对照组分别为 ９３．３％（４２／４５）和 ９３．８％（ １５／１６）；十二指肠溃疡为 ８９．１％（４１／４６）和 ８２．ｌ％（２４／２９）；无论胃溃疡或十二指肠溃疡两组对照均无明显差异（Ｐ＞０．０５）；Ｓ２获得率：胃溃疡试验组与对照组分别为６１．９％（２６／４２）和２６．７％（４／１５）；十二指肠溃疡为５８．５％（２４／４２）和２９．２％（７／２４）；无论胃溃疡和十二指肠溃疡试验组的Ｓ２获得率均明显高于对照组（Ｐ＜０．０５）。结论醋氨己酸锌能明显提高胃及十二指肠溃疡的Ｓ２获得率，研究结果表明醋氨己酸锌在提高溃疡的愈合质量中起重要作用。
OBJECTIVE: To compare the ulcer healing rate and the S2 acquisition rate of omeprazole + zinc acetimide plus omeprazole + placebo in the treatment of gastric and duodenal ulcer to evaluate the effect of zinc acteonide on ulcer healing Role. Methods: In this study, a double-blind, single-mock multicenter clinical trial was conducted in which 61 cases of gastric ulcer confirmed by endoscopy and 75 cases of duodenal ulcer were randomly divided into test group (omeprazole + zinc aceprohepionate) and control Group (omeprazole + placebo), the dose of omeprazole 20mg, qd, zinc acetate vinegar 300mg, tid; treatment: duodenal ulcer treatment for 4 weeks; gastric ulcer for 6 weeks. Results: The rate of ulcer healing was 93.3% (42/45) and 93.8% (15/16) in gastric ulcer and 89.1% (41/46) in control group, And 82. l% (24/29). There was no significant difference between the two groups in gastric ulcer or duodenal ulcer (P> 0.05). The yield of S2 was 61.9% in the experimental group and the control group 26/42) and 26.7% (4/15) respectively; duodenal ulcer was 58.5% (24/42) and 29.2% (7/24); both gastric ulcer and duodenal ulcer The experimental group obtained S2 rate was significantly higher than the control group (P <0.05). Conclusions Zinc acetohexanoate significantly increases the S2 recovery rate of gastric and duodenal ulcers. The results show that zinc acetohexanoate plays an important role in improving the healing quality of ulcer.