脑梗塞患者血小板活化状态的观察

• 作 者: 王建 刘其强 杨萍 李建章 尹明达 汪玉兰 何蕴 邢秀萍
• 机 构: 郑州河南医科大学附属第二医院神经科,中山医科大学附属第一医院神经科,开封市一院神经科
• 出 处: 中风与神经疾病杂志
• 发表日期: 1997年05期
• 关键词: 脑梗塞患者 血浆素 活化状态 梗塞灶 神经功能缺损 α-颗粒膜蛋白 急性期反应 血小板功能 高度活化 血栓烷

采用放射免疫法测定３０例脑梗塞患者血浆内血小板α颗粒膜蛋白１４０（ＧＭＰ１４０）和血栓烷Ｂ２（ＴＸＢ２）浓度。结果显示：脑梗塞患者血浆ＧＭＰ１４０浓度在急性期显著增高，恢复期降至正常；血浆ＴＸＢ２浓度在急性期和恢复期均显著增高；正常人血浆ＧＭＰ１４０和ＴＸＢ２浓度与年龄均呈显著正相关；脑梗塞患者急性期血浆ＧＭＰ１４０、ＴＸＢ２浓度与患者年龄、梗塞灶体积及神经功能缺损评分均呈正相关。提示：（１）脑梗塞患者急性期血小板高度活化，为选用抗血小板药物治疗提供了客观依据；检测血浆ＧＭＰ１４０、ＴＸＢ２浓度对病情监护、预后评估具有一定参考价值。（２）年龄是影响血小板功能的一个重要因素

Plasma platelet α-granule membrane protein 140 (GMP140) and thromboxane B2 (TXB2) concentrations were measured in 30 patients with cerebral infarction by radioimmunoassay. The results showed that: plasma concentrations of GMP 140 in patients with acute cerebral infarction were significantly increased in the recovery period to normal; plasma TXB2 concentrations were significantly increased in acute and convalescent; normal plasma GMP 140 and TXB2 concentrations and age were significant Positive correlation; acute phase of patients with cerebral infarction in plasma GMP 140, TXB2 concentration and patient age, infarct volume and neurological deficit scores were positively correlated. Tip: (1) Acute phase of platelet activation in patients with acute cerebral infarction provides an objective basis for the selection of anti-platelet drug therapy; detection of plasma GMP 140, TXB2 concentration of the disease monitoring, prognosis evaluation of a certain reference value. (2) Age is an important factor affecting platelet function